Intraocular lenses (IOLs) are artificial lenses which can be used for changing the pure lens of the attention. Mostly, they’re used to exchange lenses which were clouded by cataracts. Roughly 30 million cataract surgical procedures have been carried out worldwide in 2022.¹ Yearly this quantity will increase as a result of rising prevalence of eye situations related to the growing older inhabitants, way of life adjustments and different elements.

A number of varieties of IOLs are used for cataract surgical procedure. Globally, cataracts are a significant contributor to visible impairment. In low and middle-income international locations, cataracts are accountable for over 50% of blindness instances.² The commonest IOL is the monofocal IOL, which permits for focus at a hard and fast distance. Different varieties of IOLs, corresponding to multifocal and accommodative lenses, which permit the affected person to have completely different focusing powers throughout the identical lens. Multifocal lenses have areas throughout the lens that permit for viewing shut and distant objects. Accommodative lenses finest simulate the pure lens of the attention by making the most of the pure musculature of the attention to bodily change the refractive properties of the IOL.

As per the “World Intraocular Lens Market Worth, 2019-2029” chart, the multifocal IOL market compromised greater than half of the entire IOL market based mostly on the 2022 market worth.³ This development is predicted to be noticed over the forecast interval, with the multifocal lens market gaining market shares annually. Regardless of this quick progress, multifocal IOL models composed not more than 15% of the entire IOL models offered in 2022 globally. This disparity is as a result of excessive common promoting worth (ASP) of multifocal lenses.

In 2022, the ASP for multifocal IOLs have been virtually eight occasions greater in comparison with monofocal IOLs.³ This can stay one of many foremost elements limiting the excessive progress of multifocal IOL over the forecast interval, regardless of its quite a few benefits. This text will focus on the principle driving elements for the continued worldwide progress of IOL.

Getting old of the Inhabitants Driving IOL Market Development

Worldwide progress in IOL may be primarily attributed to the growing older of the inhabitants. As international healthcare has improved, the typical lifespan of the inhabitants has expanded. Whereas it is a constructive final result, it additionally implies that people have the next probability of reaching an age the place they could encounter age-associated situations, corresponding to cataracts. Consequently, rise of an growing older inhabitants instantly correlates with the rising incidence fee of cataracts, together with the necessity to tackle it.  

Widespread age-related eye situations embody presbyopia, glaucoma, dry eyes, age-related muscular degeneration, cataracts and others. In response to the World Well being Group, a minimum of 2.2 billion individuals have a close to or distance imaginative and prescient impairment with a minimum of 1 billion of those instances being preventable.⁴ The principle situation inflicting distance imaginative and prescient impairment or blindness are cataracts, which impacts round 95 million individuals globally.⁴

Consequently, the necessity for inexpensive and efficient therapy is important to scale back morbidity related to cataracts. Due to this fact, corporations must be ready to answer the rising demand for cataract surgical procedures.

Quite a few main opponents within the IOL market are benefiting from this market progress, in addition to some newer opponents which can be bringing novel know-how into the market. The principle opponents within the international IOL market are Alcon, J&J Imaginative and prescient Care, and Bausch & Lomb.

Elevated Incidence of Eye Circumstances

Globally, the prevalence variety of cataracts elevated by virtually 130% from 1990 to 2019.⁵ This may be attributed to a number of elements. One such issue is way of life adjustments. Particularly, elevated display time and publicity to digital gadgets contribute to earlier onset of imaginative and prescient issues which boosts the demand for IOL. Digital eye pressure (DES) encompasses a spread of ocular signs which come up from extended utilization of digital digital gadgets.

The COVID-19 pandemic’s lockdown measures curtailed out of doors actions for individuals of all ages, resulting in elevated display time. Primarily based on the statistics, the prevalence of DES signs in kids grew to 55%.⁶ Sure research point out that blue mild publicity emitted by digital screens might induce oxidative stress throughout the lens of the attention, probably taking part in a job within the growth of cataracts. Oxidative stress arises when there may be an imbalance between the manufacturing of reactive oxygen species (ROS) and the physique’s capability to counteract them. This type of oxidative harm is assumed to contribute to a spread of eye-related situations, together with the formation of cataracts.⁷ It is very important be aware that there’s nonetheless quite a lot of debate on this subject as some research recommend that elements apart from ultraviolet (UV) mild publicity may play a extra important position.

Prevalence of Diabetes

In 2021, each 1 in 10 adults was residing with diabetes, which accounts for greater than 520 million individuals.⁸ By 2045, this quantity is predicted to achieve 782 million in line with the Worldwide Diabetes Federation.⁸ People with diabetes have a notably elevated danger, starting from 2 to five time greater, of creating cataracts, which regularly manifest at an earlier stage of their lives.

There are a number of organic mechanisms that contribute to the elevated danger of creating cataracts. Mostly, elevated ranges of blood sugar in diabetes provoke a phenomenon generally known as glycation, whereby surplus sugar molecules bind to proteins throughout the lens of the attention.⁹ This interplay ends in a metamorphosis of the construction and performance of lens proteins, inducing a cloudy and fewer clear look. This opacity subsequently triggers the event of cataracts. Due to this fact, the rising prevalence of diabetes considerably impacts cataract surgical procedures.

Intraocular Lenses Analysis and Improvement

Because the demand for IOL rises annually, there are quite a few scientific analysis research aiming at enhancing the know-how. A particular space of analysis facilities on enhancing biocompatibility, reaching improved visible high quality and adjustability, minimizing surgical incisions and mitigating issues corresponding to posterior capsular opacification and ophthalmitis.¹⁰

Moreover, quite a lot of scientific analysis goals at advancing optics. This encompasses the creation of multifocal and accommodative IOLs, which permits people to realize readability of imaginative and prescient throughout completely different distances with out counting on eyeglasses. The customization of IOL is one other analysis space investigating customized IOLs to cater to the distinct visible necessities of every affected person, thereby optimizing their imaginative and prescient after surgical procedure. Furthermore, ongoing research are delving into IOLs which may be modified after being implanted, permitting for exact changes to refine the affected person’s visible acuity.¹¹

Closing Factors

The worldwide intraocular lens market has been evolving and rising dramatically up to now, and it’s anticipated to take care of progress because the wants of the inhabitants enhance. With the excessive value of most biomaterials, North America and Western Europe characterize the very best share of the entire market. Moreso, IOLs are slowly turning into extra prevalent throughout the globe. Alcon stays the main firm available in the market worldwide.

For additional insights and extra granular market knowledge, please see the report Ophthalmic System Market Dimension, Share, and Traits Evaluation – World – 2023-2029 by iData Analysis.

In regards to the Authors

Kateryna Hronska is a senior analysis analyst at iData Analysis. She works on analysis tasks relating to the medical system trade, publishing the World Diagnostic and Interventional Ophthalmic System analysis report.

Kamran Zamanian, Ph.D., is CEO and founding associate of iData Analysis. He has spent over 20 years working available in the market analysis trade with a dedication to the examine of medical gadgets used within the well being of sufferers everywhere in the globe.

About iData Analysis

For 19 years, iData Analysis has been a powerful advocate for data-driven decision-making throughout the international medical system, dental, and pharmaceutical industries. By offering customized analysis and consulting options, iData empowers its shoppers to belief the supply of information and make essential strategic choices with confidence.

Citations

• Basaldua, B. (2023, March 3). The Way forward for Cataract Surgical procedure. iOR Companions | Workplace-Primarily based Surgical procedure. 
• Tognetto, D., & Giglio, R. (2021, October 1). Synthetic Intelligence Functions and cataract administration: A scientific overview. Survey of Ophthalmology. 
• iData Analysis Inc. World Diagnostic and Interventional Ophthalmic System Market – 2023. Printed ___ 2023. Accessed ___, 2023.
• World Well being Group. (n.d.). Vision Impairment and blindness. World Well being Group. 
• Fang, R., Yu, Y.-F., Li, E.-J., Lv, N.-X., Liu, Z.-C., Zhou, H.-G., & Tune, X.-D. (2022, November 12). World, regional, nationwide burden and gender disparity of cataract: Findings from the worldwide burden of illness examine 2019 – BMC public well being. BioMed Central.
• Kaur, Okay., Gurnani, B., & Nayak, S. (2022, October). Digital Eye strain- A complete overview. Ophthalmology and remedy. 
• Nita, M., & Grzybowski, A. (2016). The position of the reactive oxygen species and oxidative stress within the pathomechanism of the age-related ocular ailments and different pathologies of the anterior and posterior eye segments in adults. Oxidative medication and mobile longevity. 
• Diabetes world wide in 2021. IDF Diabetes Atlas. (n.d.).
• Kiziltoprak, H., Tekin, Okay., & Inanc, M. (2019, March 15). Cataract in diabetes mellitus. World journal of diabetes. 
• Luo, C., Wang, H., & Chen, X. (2022, Might 23). Current advances of intraocular lens supplies and floor modification in cataract surgical procedure. Frontiers. 
• Salerno, L. C., Tiveron, M. C., & Alió, J. L. (2017). Multifocal intraocular lenses: Sorts, outcomes, issues and the way to resolve them. Taiwan journal of ophthalmology.