A brand new report has simply been launched analysing the worldwide utilization patterns and the volumes administered by model throughout aP-based hexavalent, pentavalent and college entry booster vaccines.

It examines a number of key indicators throughout toddler main collection, toddler booster and pre-school booster vaccinations in international locations that signify at the least 95% of the worldwide quantity for every class.

The function for pediatric mixture vaccines

Mixture vaccines immunise infants towards diphtheria (D), tetanus (T), pertussis (P), poliomyelitis (IPV), hepatitis B and ailments brought on by Haemophilus influenza kind b. They’re advisable for main vaccination and toddler booster administration in three or 4 doses.

Hexavalent vaccines goal all six of those ailments, while pentavalent vaccines goal all bar hepatitis B. Primarily based on the pertussis antigen element, pediatric mixture vaccines may be both DTaP (acellular pertussis) or DTwP (whole-cell pertussis). 

As a result of immunity wanes over time and youngsters are at larger threat of an infection as soon as they begin faculty, an additional booster is run between the ages of three and seven. These faculty entry booster vaccines are both trivalent (DTaP, Tdap) or tetravalent (DTaP-IPV, Tdap-IPV).

International utilization patterns

The examine finds that international demand for pediatric mixture vaccines in 2020 was 313.2 million doses, a 4.2% lower over the yr prior. It attributes the decline to healthcare measures taken in response to the COVID-19 pandemic. 

Vaccines with a whole-cell pertussis element had a 73% share by quantity. DTaP mixture vaccines accounted for the remaining 83.5 million doses. 

The report’s main focus is on aP-based mixture vaccines. These are most frequently administered in public markets (i.e. markets the place vaccines are procured and financed by the federal government quite than being paid for by non-public people or by insurance coverage schemes). Public markets are most frequently present in excessive and upper-middle revenue international locations.

The graph under reveals the general market construction, and the volumes of aP vaccines administered in tetravalent, pentavalent and hexavalent doses. 

Europe accounts for the most important share of aP-based mixture vaccines. By quantity, the area represents 38% of worldwide hexavalent vaccine consumption. For pentavalent and college entry booster vaccines, the figures are 36% and 48% respectively.

Market shares by model in 2020

Amongst the commercially obtainable manufacturers of aP-based hexavalent vaccines, Sanofi Pasteur’s Hexaxim® had a market share by quantity of 67% (roughly 22 million doses). It was adopted by Infanrix Hexa® from GSK with a share of 26%.

Within the public markets analysed, Hexaxim® commanded a good larger share of 73%. It was the clear chief in each European and emergent markets.

Within the high 33 markets, round 3.8 million doses of hexavalent vaccine have been used for preterm infants. Absolutely liquid and able to use, Hexaxim® was the one vaccine used for preterms in 16 international locations, together with Austria, Belgium, Croatia, Macedonia and Norway.

Pentaxim® (Sanofi Pasteur) was the market chief in pentavalent vaccines. Roughly 21 million doses of Pentaxim® have been administered globally in 2020, representing a quantity share of 62%. Subsequent have been Pentacel® (Sanofi Pasteur) and Pediarix® (GSK) with shares of 17% and 16%.

Amongst tetravalent faculty entry booster vaccines, Tetraxim® (Sanofi Pasteur) had a market share in extra of 47%. With 4.7 million doses administered, volumes for Tetraxim® have been almost double these of second-placed Infanrix-IPV/Kinrix®.

Primarily based on shut examination of cross-category knowledge, the report concludes that Sanofi Pasteur is the worldwide chief within the aP-based pediatric mixture vaccines market.

Discover out extra.

A White Paper To Perceive The Market Construction Of Pediatric Pertussis Mixture Vaccines comprises wealthy insights on worldwide utilization patterns for hexavalent, pentavalent and college entry booster vaccines, along with the volumes administered by model.

To obtain your copy, click on right here.